|
KMID : 0370219860300020087
|
|
Yakhak Hoeji
1986 Volume.30 No. 2 p.87 ~ p.95
|
|
|
Inclusion Complexation of Chlorpropamide with Cyclodextrins
|
|
정경혜/Jeong KH
김길수/구영순/Kim KS/Ku YS
|
|
|
Abstract
|
|
|
|
Inclusion complexation of alpha-cyclodextrin(alpha-CD), beta-cyclodextrin(beta-CD) and tri-0-methyl-beta-cyclodextrin(tri-0-methyl-beta-CD) with chlorpamide(CPA) in aqueous solution and in the solid state were studied by the solubility method, spectroscopy (UV, IR), differential scanning calorimetry (DSC) and powder X-ray diffractometry, and all their molar ratios were found to be 1:1. The solid complexes of CPA with three kinds of cyclodextrins were prepared by a freeze-drying method, and their dissolution behaviors were examined. As a result, the release of CPA from the inclusion complexes was significantly improved. The intrinsic dissolution rate of CPA in cyclodextrin inclusion complexes was about 51 times (alpha-CD inclusion complex) and 12 times (beta-CD inclusion complex) larger than that of intact CPA.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|